Precautions and Warnings With Avanafil

Specific Avanafil Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Phosphodiesterase type-5 (PDE5) inhibitors, including avanafil, have been associated with serious heart and blood vessel (cardiovascular) side effects, such as heart attacks and strokes. Sexual activity can put strain on your heart, especially if you already have heart problems or have had a heart attack. You should not use avanafil if your heart is not healthy enough for sex.
  • Avanafil can cause dangerously low blood pressure (hypotension), especially if taken in combination with certain other medicines, such as nitrates (see Drug Interactions With Avanafil). If your blood pressure becomes too low, you could become dizzy or faint. If you feel dizzy or faint while taking avanafil, stop using the medicine and talk to your healthcare provider about your symptoms.
  • Stop using avanafil and seek immediate medical attention if you experience a sudden decrease or loss of vision in one or both eyes. Vision loss could be a sign of a rare condition known as nonarteritic anterior ischemic optic neuropathy (NAION). NAION has been reported in people taking PDE5 inhibitors, such as avanafil. Vision loss from NAION can be permanent.
  • There have been reports of decreased hearing and hearing loss, sometimes with dizziness and ringing in the ears, in people taking PDE5 inhibitors like avanafil. Seek immediate medical attention if you develop a change in hearing, with or without dizziness and ringing in the ears.
  • There have been rare cases of prolonged or painful erections (medically known as priapism) in people taking PDE5 inhibitors, including avanafil. Seek immediate medical care if you experience an erection that lasts longer than four hours. If not treated immediately, this condition can cause permanent damage to the penis and impotency.
  • You should know that avanafil will not protect you against sexually transmitted diseases (STDs), including infection with the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). Avanafil will also not prevent pregnancy. Although this seems obvious, it is an important warning, especially for people who may have an incomplete understanding of what avanafil does and how it works.
  • Consuming alcohol while using avanafil can cause an increased heart rate, low blood pressure (especially when standing up), dizziness, and headaches. Do not consume more than three drinks of alcohol, such as three glasses of wine or three shots of liquor, while taking avanafil.
  • At this time, it is unknown if avanafil is safe for use in people with bleeding conditions or stomach ulcers (peptic ulcers). If you have a bleeding problem or a stomach ulcer, talk to your healthcare provider about this before taking avanafil.
  • Avanafil is a pregnancy Category C medication, which means it may not be safe for use in pregnant women (see Stendra and Pregnancy). Avanafil is not approved for use in women.
  • It is unknown if avanafil passes through breast milk (see Stendra and Breastfeeding). Avanafil is not approved for use in women.
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Avanafil Medication Information

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