Drug Interactions With the Diclofenac Patch

Diuretics
Combining diclofenac patch with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking diclofenac patch and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining diclofenac patch with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine diclofenac patch with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Diclofenac patch may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of diclofenac patch in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
Skin Products
It is best to avoid using other skin products on the same area as diclofenac patch. It is not known how such products might affect diclofenac patch.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with diclofenac patch may increase the risk of bleeding. Check with your healthcare provider before taking diclofenac patch with an SSRI or SNRI.
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Diclofenac Patch Drug Information

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