Drug Interactions With the Diclofenac Patch

A number of medications may cause diclofenac patch drug interactions, including methotrexate, cyclosporine, ACE inhibitors, and anticoagulant or antiplatelet drugs. Some interactions can reduce the effectiveness of the medicines, while others may increase your risk for developing side effects or complications. In order to help prevent interactions, make sure to tell your healthcare provider about all other medications you are taking.

An Overview of Diclofenac Patch Interactions

Even though the diclofenac patch (Flector® Patch) is applied to the skin, it can potentially interact with several other medications (since some of the medication is absorbed into the bloodstream). Some of the medicines that may lead to drug interactions with the diclofenac patch include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with the diclofenac patch and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
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Diclofenac Patch Drug Information

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