Drug Interactions With the Diclofenac Patch

A number of medications may cause diclofenac patch drug interactions, including methotrexate, cyclosporine, ACE inhibitors, and anticoagulant or antiplatelet drugs. Some interactions can reduce the effectiveness of the medicines, while others may increase your risk for developing side effects or complications. In order to help prevent interactions, make sure to tell your healthcare provider about all other medications you are taking.

An Overview of Diclofenac Patch Interactions

Even though the diclofenac patch (Flector® Patch) is applied to the skin, it can potentially interact with several other medications (since some of the medication is absorbed into the bloodstream). Some of the medicines that may lead to drug interactions with the diclofenac patch include:
 
  • ACE inhibitors, including:

 

 

  • Anticoagulant and antiplatelet drugs, such as:

 

    • Aspirin (Bayer® and others)
    • Cilostazol (Pletal®)
    • Clopidogrel (Plavix®)
    • Dipyridamole (Persantine®)
    • Eptifibatide (Integrilin®)
    • Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
    • Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

 

  • Certain diuretics, such as:

 

 

  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Lithium (Eskalith®, Lithobid®)
  • Methotrexate (Rheumatrex®)
  • Skin products such as cosmetics, lotions, or creams.
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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