Drug Interactions With Dutasteride/Tamsulosin

More Detail on Drug Interactions With Dutasteride/Tamsulosin

The following sections explain in detail the potential problems that can occur when dutasteride/tamsulosin is combined with any of the drugs mentioned above.
Alpha Blockers
Taking dutasteride/tamsulosin in combination with other alpha blockers may lead to low blood pressure (hypotension). If your blood pressure drops too low, you may experience symptoms such as dizziness, lightheadedness, or fainting. Because of the risk of dangerously low blood pressure, it is best to avoid using dutasteride/tamsulosin with other alpha blockers.
Beta Blockers
Taking dutasteride/tamsulosin in combination with a beta blocker may lead to low blood pressure (hypotension). Although this risk is less likely to occur with dutasteride/tamsulosin than with other alpha blockers, it may still be possible, especially when you first start using dutasteride/tamsulosin. Therefore, if you are currently taking a beta blocker, watch for signs of low blood pressure, such as dizziness or lightheadedness, for the first couple of days after starting dutasteride/tamsulosin.
If you do feel dizzy, it is a good idea to sit or stand slowly to reduce your risk of falling down. Also, make sure you have something stable to hold onto when sitting up or standing up.
CYP 2D6 Inhibitor Medications
The body breaks down dutasteride/tamsulosin using enzymes in the liver known as CYP 2D6 enzymes. Certain other medications (known as CYP 2D6 inhibitors) can decrease the activity of these enzymes. Combining dutasteride/tamsulosin with one of these CYP 2D6 inhibitors may increase the level of dutasteride/tamsulosin in your body, increasing your risk for more side effects. Talk to your healthcare provider about your options if you are taking a CYP 2D6 inhibitor.
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Dutasteride/Tamsulosin Drug Information

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