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Insulin, warfarin, and cortisone are just a few of the drugs that are known to interact with Axiron. Depending on the particular interaction, problems such as liver damage, fluid retention, and decreased blood sugar are possible. To reduce your risk of potentially serious problems, tell your healthcare provider about all other medicines and supplements you are taking.

An Overview of Interactions With Axiron

Axiron® (testosterone topical solution) can potentially react with several other medications. Some of these drugs that may interact with Axiron include:
  • Insulin
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

Axiron Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Axiron is combined with any of the drugs listed above.
Axiron can decrease blood sugar. If you take insulin, you should monitor your blood sugar more closely when starting or stopping Axiron, or even when adjusting your dose. You may need to adjust your insulin dosage. Check with your healthcare provider for more specific instructions based on your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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