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In clinical studies, common side effects of Axiron included armpit irritation, armpit redness, and vomiting, among others. However, most men tolerated it well, and the reported reactions were usually mild and easy to treat. Axiron may also increase the body's levels of prostate-specific antigen or hematocrit. If this happens in your case, your healthcare provider may recommend stopping this medication.

An Introduction to Axiron Side Effects

As with any medicine, side effects are possible with Axiron® (testosterone topical solution). However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Axiron. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Axiron

Axiron has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of men using the drug were carefully documented. The most commonly reported reactions to Axiron included:
  • Armpit irritation -- in up to 8 percent of men
  • Armpit redness -- up to 7 percent
  • Headache -- up to 6 percent
  • Diarrhea -- up to 4 percent
  • Vomiting -- up to 4 percent.
In addition, up to 7 percent of men using Axiron had an increased hematocrit (a measure of red blood cells), and up to 4 percent had increased prostate-specific antigen (PSA) levels. Some men may need to stop using the medication due to these side effects.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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