Men Home > Precautions and Warnings With Doxazosin XL

Before using doxazosin XL, there are many precautions to be aware of, including warnings relating to who should not use the medication and possible side effects that may occur. For example, this prescription drug may cause dangerously low blood pressure and may not be safe for people who have liver disease, chest pain, or a history of a heart attack.

What Should I Tell My Healthcare Provider Before Taking Doxazosin XL?

You should talk with your healthcare provider prior to taking doxazosin XL (Cardura® XL) if you have:
Also, let your healthcare provider know if you:
  • Have an upcoming cataract surgery
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Doxazosin XL Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medicine include the following:
  • Doxazosin XL can cause low blood pressure (hypotension). This can be especially severe in people who already have low blood pressure or who take blood pressure medications. Doxazosin XL commonly causes dizziness, which may interfere with your ability to drive, operate heavy machinery, or focus mentally.
  • Medications like doxazosin XL have been reported to cause Intraoperative Floppy Iris Syndrome, a problem with the eyes that can occur during cataract surgery. Stopping the medication before surgery probably does not prevent this problem from occurring. Before having eye surgery, make sure to tell your healthcare provider if you have been on doxazosin XL.
  • Doxazosin XL should not be used in people with severe liver disease, as the potential risks in these cases have not been adequately studied.
  • The outer shell of doxazosin XL tablets does not dissolve. It is normal to notice them in your stools. This type of tablet can rarely cause intestinal blockages in people with strictures of the gastrointestinal tract.
  • Doxazosin XL has not been studied in people with congestive heart failure, chest pain, or a history of a recent heart attack. If you notice new or worsening chest pain while taking this medication, seek immediate medical attention.
  • Doxazosin XL is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are unknown (see Cardura XL and Pregnancy). Importantly, doxazosin XL is not approved for any use in women.
  • It is not known if doxazosin XL passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Cardura XL and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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