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The approved use of Ifex includes the treatment of testicular cancer in adults. Specifically, this chemotherapy drug is approved to treat germ cell testicular cancer after at least two other treatments have failed. There are also some unapproved, or off-label, uses for this medication, such as treating lung cancer, ovarian cancer, and various other types of cancer.

What Is Ifex Used For?

Ifex® (ifosfamide) is a prescription chemotherapy medication that belongs to a group of medicines known as alkylating agents. It is approved for use in combination with other chemotherapy medicines to treat testicular cancer (cancer of the testicles).

What Is Testicular Cancer?

Testicular cancer occurs when cancer cells begin to form in one or both testicles, although normally only one testicle is affected. The testicles are the male reproductive organs located beneath the penis. They sit inside the scrotum.
Testicular cancer is generally rare, accounting for only about 1 percent of all cancers in men in the United States. However, it is the most common form of cancer in men between the ages of 15 and 34.
Most testicular cancer begins from germ cells, the cells of the testicles that make sperm. Ifex is approved specifically for the treatment of germ cell testicular cancer.
Testicular cancer usually responds well to treatment, with more than 95 percent of cases being cured. In general, treatments will vary, depending in part on the type of cancer and how much the disease has progressed. Treatment may include:
Ifex is considered a third-line chemotherapy treatment. This means it is used after at least two other treatments have been tried unsuccessfully.
Because Ifex is associated with a potentially serious irritation of the bladder known as hemorrhagic cystitis, it is given in combination with a medication called mesna (Mesnex®). Mesna protects the bladder and helps reduce the chance of developing hemorrhagic cystitis.
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Last reviewed by: Kristi Monson, PharmD;
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