Striant is a testosterone medication that comes in the form of a special tablet that is applied to the gums. This makes it possible for the testosterone to be released slowly and directly into the bloodstream. It is a Schedule III controlled substance, so strict regulations control its sale and use. Possible side effects include pain, tenderness, and irritation of the gums.
What Is Striant?
Striant™ (testosterone buccal tablet) is a prescription medication approved to treat low testosterone levels in adult men due to various causes. It comes in a uniquely designed tablet that adheres to the cheeks or gums in the mouth (such tablets are known as "buccal tablets"). Testosterone is gradually absorbed directly through the cheeks or gums.
As an anabolic steroid, Striant is classified as a Schedule III controlled substance in the United States. This means that special laws and regulations control its sale and use.
Striant is made by Mipharm S.p.A for Columbia Laboratories, Inc.
How Does It Work?
Striant contains the hormone testosterone in a special buccal tablet that is applied to the gums twice a day. The tablet slowly releases testosterone that is directly absorbed through the cheeks and gums into the bloodstream. It helps increase testosterone to a normal level.
Striant is used as a buccal tablet, not a regular tablet that is swallowed, because it would have little effect on testosterone levels if it were swallowed. When medications are taken by mouth, they must first pass through the liver before they reach the bloodstream. The liver metabolizes testosterone extensively before it has a chance to reach the bloodstream, and significant blood levels of the medication cannot be achieved.
However, when testosterone is absorbed through the cheeks and gums, it bypasses the liver, allowing significant amounts of the hormone to reach the bloodstream.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Striant [package insert]. Livingston, NJ: Columbia Laboratories, Inc.;2004 November.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed January 17, 2011.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
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