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If certain medications are used in combination with testosterone cypionate injections, there is a possibility for drug interactions. Specifically, testosterone cypionate should not be combined with insulin, corticosteroids, cyclosporine, or warfarin. These reactions may lead to serious complications, such as liver damage, bleeding, or fluid retention.

An Overview of Testosterone Cypionate Interactions

Testosterone cypionate (Depo®-Testosterone) may react with several other medications. Some of the drugs that may cause interactions include but are not limited to:
 
  • Insulin of any kind
  • Corticosteroids, such as:
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 

Drug Interactions With Testosterone Cypionate Explained

The following sections explain in detail the potentially negative reactions that can occur when testosterone cypionate is combined with any of the drugs listed above.
 
Insulin
Testosterone cypionate can decrease blood sugar levels. If you take insulin, you should monitor your blood sugar levels more closely when starting or stopping testosterone cypionate, or even when adjusting your dose. You may need to adjust your insulin dose. Check with your healthcare provider for more specific instructions for your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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