Men Home > Drug Interactions With the Testosterone Patch

If warfarin, corticosteroids, insulin, or certain other drugs are combined with testosterone patches, interactions can occur. Some of these reactions may cause fluid retention, dangerous bleeding, or kidney problems. To prevent these and other possible complications, your healthcare provider may need to adjust your dosages or monitor you more closely.

An Overview of Testosterone Patch Interactions

The testosterone patch (Androderm®) may react with a number of other medications. Some of the drugs that can lead to interactions with the testosterone patch include but are not limited to:
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

More Detail on Drug Interactions With the Testosterone Patch

The following sections explain in detail the potentially negative reactions that can occur when the testosterone patch is combined with any of the drugs listed above.
Combining the testosterone patch with a corticosteroid could increase the risk for fluid retention (edema). This could cause problems, especially in people with heart or liver disease. Check with your healthcare provider before using a testosterone patch with a corticosteroid.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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