Drug Interactions With Megestrol

There is a possibility that certain drugs may interfere with megestrol. Interactions with this medication may occur when it is taken with cyclosporine, aminoglutethimide, dofetilide, and indinavir. Some of these reactions may result in complications, such as an increased risk for side effects or a reduced effectiveness of the medications.

An Overview of Megestrol Interactions

Megestrol acetate (Megace®) may react with a number of other products. Some of the drugs that can interact with megestrol include but are not limited to:
 
 

More Information on Drug Interactions With Megestrol

The following sections explain in detail the potentially negative interactions that can occur when megestrol is combined with any of the drugs listed above.
 
Aminoglutethimide
Aminoglutethimide may decrease blood levels of megestrol, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together to make sure megestrol is working for you.
 
Cyclosporine
Megestrol may increase the level of cyclosporine in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely and give you a lower cyclosporine dosage if you take these medications together.
 
Dofetilide
Megestrol can increase the level of dofetilide in your blood, which could increase the chance of developing potentially serious side effects. The manufacturer of dofetilide recommends these medicines not be used together.
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Megestrol Acetate Drug Information

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