Megestrol Side Effects

Common Side Effects

Megestrol has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were documented and (in some studies) compared to those that occurred in a similar group of people given a placebo (a medication that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
 
In studies of megestrol oral suspension, the most common side effects included:
 
  • Diarrhea -- in up to 15 percent of people
  • Impotence (erectile dysfunction, or ED) -- up to 14 percent
  • Rash -- up to 12 percent
  • Headache -- up to 10 percent
  • Gas -- up to 10 percent
  • High blood pressure (hypertension) -- up to 8 percent
  • Weakness or lack of energy -- up to 6 percent
  • Insomnia -- up to 6 percent
  • High blood sugar levels (hyperglycemia) -- up to 6 percent
  • Pain -- up to 6 percent
  • Vomiting -- up to 6 percent
  • Fever -- up to 6 percent.
 
Other common reactions, occurring in 2 percent to 5 percent of people, included:
 
  • Nausea
  • Anemia (low red blood cells)
  • Decreased sex drive
  • Heartburn or indigestion
  • Pneumonia
  • Increased urination
  • Abdominal (stomach) pain
  • Chest pain
  • Infection of any kind
  • Yeast infection
  • A pounding or racing heartbeat
  • Constipation
  • Dry mouth
  • An increase in saliva
  • Decrease in white blood cells
  • Swelling of the body, especially the arms, hands, legs, ankles, or feet
  • Tingling, burning, pricking, or numbness of the skin
  • Confusion
  • Depression
  • Abnormal thinking
  • Seizure
  • Shortness of breath
  • Cough
  • Hair loss
  • Itching
  • Sweating
  • Lazy eye (known medically as amblyopia)
  • Enlarged breasts in men
  • Loss of bladder control
  • Abnormal amounts of albumin (a protein found in the body) in the urine.
 
Megestrol tablet is an older medication. Like other older medications, the prescribing information includes only vague information on possible side effects, with no exact percentages. Therefore, it can be difficult to know exactly how common these reactions may be.
 
Megestrol tablets can be expected to have the same side effects as megestrol oral suspension. In addition to the side effects listed earlier, the tablets may cause:
 
  • Weight gain
  • Swelling of the arms, hands, legs, ankles, or feet
  • Bleeding between menstrual periods
  • Shortness of breath
  • Hair loss (alopecia)
  • Hot flashes
  • General feelings of discomfort or illness
  • Sweating
  • Carpal tunnel syndrome
  • A temporary worsening of cancer symptoms.
 
Men and Osteoporosis

Megestrol Acetate Drug Information

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