Methitest Warnings and Precautions

Because Methitest is not suitable for certain people, make sure your healthcare provider knows if you have any allergies or if you are pregnant or breastfeeding. The safety precautions for Methitest also include warnings of potential complications this drug might cause, such as fluid retention or an enlarged prostate. In addition, this medication can increase the risk of liver problems, including liver cancer.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Methitest® (methyltestosterone tablets) if you have:
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
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Make sure to tell your healthcare provider about any medications you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements.
 

Specific Warnings and Precautions With Methitest

Warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Women taking Methitest (usually for breast cancer) should report any signs of virilization to their healthcare providers right away. Symptoms may include:
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    • A deepening voice
    • Body and/or facial hair
    • Clitoral enlargement
    • Menstrual irregularities.
If Methitest is stopped early on, the virilization may be at least partially reversible. If the drug is stopped later, the virilization may be permanent. However, you and your healthcare provider may decide for you to keep taking Methitest, despite virilization, if the benefits to you are significant.
  • Methitest can cause or worsen an enlarged prostate. It also appears to increase the risk of prostate cancer. Your healthcare provider should evaluate you for prostate cancer before you start the medication and periodically thereafter.
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  • This drug can potentially decrease sperm count, thereby decreasing fertility (although it can also help with certain causes of infertility related to low testosterone). Consult your healthcare provider if you experience difficulty conceiving a child while taking Methitest.
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  • Make sure to contact your healthcare provider right away if you develop symptoms of high blood calcium levels (hypercalcemia), such as:
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    • Constipation, nausea, or vomiting
    • Muscle achiness or weakness
    • Kidney stones
    • Abdominal (stomach) pain or side pain
    • Confusion or lethargy
    • Increased thirst and frequent urination.
 
  • Methitest can increase the risk of liver problems, including liver cancer. Your healthcare provider needs to monitor your liver function periodically during treatment using standard blood tests.
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  • There is some thought that oral methyltestosterone use (such as with Methitest) is more likely to cause liver problems than treatment with other forms of testosterone, such as testosterone injections, creams, or patches. For this reason, oral methyltestosterone therapy has fallen out of favor and has largely been replaced by other forms of testosterone replacement.
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  • Androgens can cause fluid retention, which can be dangerous for people with liver, heart, or kidney disease.
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  • Your healthcare provider may want to monitor your cholesterol more closely while you are on this medication.
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  • Methitest can cause bone problems when given to adolescents. These problems can result in a shorter-than-expected stature. A healthcare provider will need to monitor the adolescent's bones at least once every six months during treatment.
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  • Breast enlargement can occur in men taking Methitest.
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  • This medication can worsen, or possibly even cause, sleep apnea.
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  • Methitest can potentially react with a few other medications (see Methitest Drug Interactions).
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  • This product is considered a pregnancy Category X medication. This means it is definitely not safe for use during pregnancy (see Methitest and Pregnancy).
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  • This medication is not safe for use during breastfeeding (see Methitest and Breastfeeding).
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Methitest Medication Information

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