Drug Interactions With Orally Disintegrating Vardenafil

More Detail on Drug Interactions With Orally Disintegrating Vardenafil

The following sections explain in detail the potential problems that can occur when orally disintegrating vardenafil is combined with any of the drugs mentioned above.
 
Alpha Blockers
Taking orally disintegrating vardenafil in combination with an alpha blocker may lead to low blood pressure (hypotension). If your blood pressure drops too low, you may experience symptoms such as dizziness, lightheadedness, or fainting.
 
People who do combine an alpha blocker with a PDE5 inhibitor (such as orally disintegrating vardenafil) are usually started on low doses of the PDE5 inhibitor. Because orally disintegrating vardenafil only comes in one dose, your healthcare provider may recommend another medication for erectile dysfunction if you take an alpha blocker.
 
Blood Pressure Medications
Taking orally disintegrating vardenafil in combination with a high blood pressure medication may cause your blood pressure to decrease too much. If your blood pressure drops too low, you may experience symptoms such as dizziness, lightheadedness, or fainting. If you take blood pressure medications, make sure to talk to your healthcare provider before taking orally disintegrating vardenafil.
 
Class I and Class III Arrhythmia Medications
You should not take orally disintegrating vardenafil with medications that are used to treat an abnormal heart rhythm. Taking these medications together increases the risk of QT prolongation, a dangerous type of arrhythmia.
 
CYP 3A4 Inducer Medications
The body breaks down orally disintegrating vardenafil using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining orally disintegrating vardenafil with one of these CYP 3A4 inducers may decrease the level of orally disintegrating vardenafil in your body, making it less effective. Talk to your healthcare provider about your options if you take a CYP 3A4 inhibitor.
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