Rogaine Drug Interactions

Although Rogaine is applied to the scalp, it is possible for enough of the medication to be absorbed into the bloodstream to cause negative reactions with other medicines. Some of these reactions can lower your blood pressure to unsafe levels or cause other side effects. Certain topical medications, blood pressure medications, and prostacyclin analogs are among the medications that can lead to interactions with Rogaine.

An Overview of Interactions With Rogaine

Rogaine® (minoxidil) is an over-the-counter (OTC) medication used to treat male and female pattern baldness. It may potentially interact with several other medications.
(This article applies only to minoxidil formulations that are applied on the scalp. An oral form of minoxidil is available by prescription and is used to treat severe hypertension. Oral minoxidil should not be used to treat hair loss, as it can cause serious side effects. Click Loniten for more information.)
Rogaine is applied directly to the scalp. Although very little of the medication is expected to be absorbed into the bloodstream after normal use, in some cases (such as if the medication is applied to an inflamed or irritated scalp), enough of the medication may be absorbed to cause drug interactions. Additionally, Rogaine should not be used with other medications that are applied on the scalp.
Some of the drugs that may lead to Rogaine interactions include but are not limited to:


  • Prostacyclin analogs, such as:
    • Epoprostenol (Flolan®, Veletri®)
    • Iloprost (Ventavis®)
    • Treprostinil (Remodulin®, Tyvaso®)
  • Rituximab (Rituxan®)
  • Topical medications applied directly on the scalp, such as:
    • Corticosteroid creams and ointments, such as hydrocortisone (Cortaid®, Cortizone®, and several other products) or triamcinolone (Triderm® and several other products)
    • Petrolatum or petroleum jelly (Vaseline®)
    • Retinoid creams or gels, such as bexarotene (Targretin®) and tretinoin (Atralin™, Avita®, Renova®, Retin-A®, Tretin-X™).
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Rogaine Medication Information

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