Drug Interactions With Sildenafil Citrate

More Details on Interactions With Sildenafil Citrate

The following sections explain in detail the potentially negative interactions that can occur when sildenafil is combined with any of the drugs listed above.
In previous research studies, when cimetidine and sildenafil citrate were given at the same time, the levels of Viagra in the blood increased significantly. To avoid this possible sildenafil citrate drug interaction, it is recommended that you discuss alternatives with your healthcare provider prior to taking sildenafil citrate.
CYP 3A4 Inhibitors
Sildenafil is broken down ("metabolized") by certain enzymes in the liver known as CYP 3A4 enzymes. Certain other medications (known as CYP 3A4 inhibitors) decrease the activity of the enzymes, thereby increasing the level of sildenafil in the blood. This may lead to serious side effects in some cases. Check with your healthcare provider before taking sildenafil with a CYP 3A4 inhibitor.
Alpha Blockers
In previous research studies, when alpha blockers and sildenafil citrate were used at the same time for people with benign prostatic hyperplasia (BPH) or high blood pressure, blood pressure decreased. Also, some people who took these medicines together experienced lightheadedness, dizziness, or fainting when standing from either a sitting position or lying down. Check with your healthcare provider before taking sildenafil with an alpha blocker.
Blood Pressure Medications
Taking sildenafil in combination with a high blood pressure medication may cause your blood pressure to decrease too much. Check with your healthcare provider before taking sildenafil with a blood pressure medicine.
If you are taking nitrates, you should not use sildenafil citrate. Even if you use a nitrate very infrequently, you should not take sildenafil (since you cannot predict when you will need to take the nitrate).
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