Precautions and Warnings With Silodosin

There are many precautions and warnings with silodosin to be aware of, such as knowing who should not use this drug. You should not take silodosin if you have severe liver or kidney disease. It is also important to know that silodosin may cause low blood pressure, which can be especially severe in people who already have the condition or who take blood pressure medications.

What Should I Tell My Healthcare Provider Before Taking Silodosin?

You should talk with your healthcare provider prior to taking silodosin (Rapaflo) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Low blood pressure (hypotension)
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Will be having cataract surgery
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions for Silodosin

Some precautions and warnings to be aware of prior to taking silodosin include the following:
  • Silodosin can cause low blood pressure (hypotension). This can be especially severe in people who already have low blood pressure or who take blood pressure medications. Silodosin commonly causes dizziness, which may interfere with your ability to drive, operate heavy machinery, or focus mentally.
  • The kidneys help remove silodosin from the body. If you have kidney disease, a lower silodosin dosage may be recommended, and your healthcare provider may need to monitor your response to silodosin more closely.
  • Before you start silodosin, your healthcare provider should make sure your enlarged prostate symptoms are not caused by another condition, such as prostate cancer or bladder problems.
  • Medications like silodosin have been reported to cause intraoperative floppy iris syndrome, a problem with the eyes that can occur during cataract surgery. Stopping silodosin before surgery probably does not prevent this problem from occurring. Before having eye surgery, be sure to tell your healthcare provider if you have been on silodosin.
  • Silodosin has not been studied in men with severe liver disease. Therefore, it is not recommended in such people.
  • Silodosin can potentially interact with many other medications (see Drug Interactions With Silodosin).
  • Silodosin is considered a pregnancy Category B medication. This means that it probably will not cause problems if used during pregnancy, although the full risks are not currently known (see Rapaflo and Pregnancy). Importantly, silodosin is not approved for any use in women.
  • It is not known if silodosin passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Rapaflo and Breastfeeding).
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Silodosin Drug Information

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