Drug Interactions With Tadalafil

Tadalafil Interactions Explained

The following sections explain in detail the following interactions that can occur when tadalafil is combined with any of the drugs listed above.
 
Alcohol
Taking tadalafil with a significant amount of alcohol can cause a fast heart rate (tachycardia), low blood pressure (hypotension), dizziness, and headache.
 
CYP 3A4 Inhibitors
Tadalafil is broken down ("metabolized") by certain enzymes in the liver known as CYP 3A4 enzymes. Certain other medications (known as CYP 3A4 inhibitors) decrease the activity of the enzymes, thereby increasing the level of tadalafil in the blood. This may lead to serious side effects in some cases. Check with your healthcare provider before combining these medications.
 
Alpha Blockers
Combing tadalafil with an alpha blocker can cause low pressure, including dangerously low blood pressure in some cases. Check with your healthcare provider before taking these drugs together.
 
Blood Pressure Medications
Taking tadalafil with a high blood pressure medication may cause your blood pressure to decrease too much. Check with your healthcare provider before combining these drugs.
 
Nitrates
If you are taking nitrates, you should not use tadalafil. Even if you use a nitrate infrequently, you should not take tadalafil, since you cannot predict when you will need to take the nitrate.
 
Other Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Tadalafil is a PDE5 inhibitor and should not be combined with other such medications, even if they are not used to treat erectile dysfunction.
 
Theophylline
Taking theophylline and tadalafil together may cause a slight increase in heart rate. Your healthcare provider may choose to make necessary dosing adjustments if you need to take both of these drugs. 
 
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