Precautions and Warnings for Tadalafil

Some Precautions and Warnings for Tadalafil

Here are some precautions and warnings to be aware of when taking tadalafil:
  • Several medications can interact with tadalafil (see Drug Interactions With Tadalafil).
  • If you have cardiovascular disease or significant heart disease risk factors, there is an increased chance of serious side effects. In rare cases, problems with the heart, brain, and blood vessels are seen in people taking tadalafil. These problems can result in side effects such as heart attack, stroke, or sudden death (see Side Effects of Tadalafil).
  • In people taking tadalafil or other PDE5 inhibitors, there have been rare cases of a condition called non-arteritic anterior ischemic optic neuropathy (NAION). This condition can lead to sudden loss of vision in one or both eyes. If you experience any loss of vision, contact your doctor immediately (see Cialis and Blindness).
  • The FDA considers tadalafil a pregnancy Category B medicine, meaning that while the drug has not been studied in pregnant women, it showed no negative effects on unborn babies in previous animal studies. However, tadalafil is not licensed for use in female patients.


  • There have been reports of tadalafil causing hearing problems. Stop taking tadalafil and immediately contact your healthcare provider if you notice a sudden decrease in or loss of hearing. 


  • Very rarely, people on tadalafil can experience a prolonged erection, which in some cases can be painful. If you experience an erection for longer than four hours while taking tadalafil, contact your healthcare provider immediately.
  • Tadalafil does not offer protection against sexually transmitted diseases (STDs).
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