Precautions and Warnings With Testosterone Cypionate

While testosterone cypionate has been shown to effectively increase testosterone levels in many men, this medicine may not be safe for some people. For example, if you have serious heart, liver, or kidney disease, you should not use testosterone cypionate. Warnings and safety precautions with this drug also relate to potential drug interactions and allergic reactions.

What Should I Tell My Healthcare Provider Before Using Testosterone Cypionate?

Talk with your healthcare provider prior to using testosterone cypionate (Depo®-Testosterone) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Testosterone Cypionate Precautions and Warnings

Some warnings and precautions to be aware of prior to receiving this medicine include the following:
  • Testosterone cypionate can cause or worsen an enlarged prostate. It also appears to increase the risk for prostate cancer. Your healthcare provider should evaluate you for prostate cancer before you start the medication and periodically thereafter.
  • Testosterone cypionate can potentially decrease sperm count, thereby decreasing fertility (although it can also help with certain causes of infertility related to low testosterone). Consult your healthcare provider if you experience difficulty conceiving a child while using this medicine.
  • Androgens can increase the risk for liver problems, including liver cancer. Although these problems have not been reported with testosterone cypionate, they cannot be completely ruled out.
  • Androgens can cause fluid retention, which can be dangerous for people with liver, heart, or kidney disease.
  • Breast enlargement can occur in men using testosterone cypionate.
  • This medication can cause or worsen sleep apnea.
The Dirty, Messy Part of BPH

Testosterone Cypionate Drug Information

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