Precautions and Warnings With Testosterone Enanthate

Before starting testosterone enanthate, the drug's warnings and precautions should be reviewed. For example, it is important to know that this injection can increase your risk of liver problems and cause virilization (the development of male characteristics) in women. You should not use testosterone enanthate if you are pregnant, have certain allergies, or are a man with breast or prostate cancer.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to starting testosterone enanthate (Delatestryl®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements.

Specific Testosterone Enanthate Warnings and Precautions

Warnings and precautions to be aware of prior to using this drug include the following:
  • Women using testosterone enanthate (usually for breast cancer) should report any signs of virilization to their healthcare providers right away. Symptoms of virilization include:
    • A deepening voice
    • Body and/or facial hair
    • Clitoral enlargement
    • Menstrual irregularities.
If testosterone enanthate is stopped early on, the virilization may be at least partially reversible. If the drug is stopped later, the virilization may be permanent. However, you and your healthcare provider may decide for you to keep using testosterone enanthate, despite virilization, if the benefits to you are significant.
  • Testosterone enanthate can cause or worsen an enlarged prostate. It also appears to increase the risk of prostate cancer. Your healthcare provider should evaluate you for prostate cancer before you start the medication and periodically thereafter.
  • This medication can potentially decrease sperm count, thereby decreasing fertility (although it can also help with certain causes of infertility related to low testosterone). Consult your healthcare provider if you experience difficulty conceiving a child while using testosterone enanthate.
  • Make sure to contact your healthcare provider right away if you develop symptoms of high blood calcium levels (hypercalcemia), such as:
    • Constipation, nausea, or vomiting
    • Muscle achiness or weakness
    • Kidney stones
    • Abdominal (stomach) pain or side pain
    • Confusion or lethargy
    • Increased thirst and frequent urination.
  • Androgens can increase the risk of liver problems, including liver cancer. Although these problems have not been reported with testosterone enanthate, they cannot be completely ruled out.
  • Androgens can cause fluid retention, which can be dangerous for people with liver, heart, or kidney disease.
  • Your healthcare provider may want to monitor your cholesterol more closely while you are on this medication.
  • Testosterone enanthate can cause bone problems when given to adolescents. These problems can result in a shorter-than-expected stature. A healthcare provider will need to monitor the adolescent's bones at least once every six months during treatment.
  • Breast enlargement can occur in men using testosterone enanthate.
  • This medication can worsen (or possibly even cause) sleep apnea.
  • Testosterone enanthate can potentially react with a few other medications (see Drug Interactions With Testosterone Enanthate).
  • Testosterone enanthate is considered a pregnancy Category X medication. This means it is definitely not safe for use during pregnancy (see Delatestryl and Pregnancy).
  • This medication is not safe for use during breastfeeding (see Delatestryl and Breastfeeding).
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Testosterone Enanthate Drug Information

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