Drug Interactions With Vardenafil

Vardenafil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when vardenafil is combined with any of the drugs listed above.
Alpha Blockers
In previous research studies, when alpha blockers and vardenafil were used at the same time for people with high blood pressure or benign prostatic hyperplasia (BPH), blood pressure decreased. Some people experienced lightheadedness, dizziness, or fainting when standing up from either a sitting or lying position. Your healthcare provider may recommend a lower dosage of vardenafil if you are also taking an alpha blocker.
Arrhythmia Medicine
People taking certain medicines to treat an abnormal heart rhythm should not take vardenafil. These medications include quinidine, procainamide, amiodarone, and sotalol. Combining one of these medications with vardenafil increases the risk of a very dangerous arrhythmia called QT prolongation.
Certain Antibiotics or Antifungals
Taking certain antibiotics and antifungals with vardenafil can increase the level of vardenafil in your blood, increasing your risk of side effects. If taking these medications together, you should talk with your healthcare provider about your recommended vardenafil dosage. For people taking these medications, the dose may be limited to a maximum of vardenafil 2.5 mg or 5 mg in a 24-hour period, depending on the particular drug and dosage.
Grapefruit Juice
Although studies have not been done to see if grapefruit juice interacts with vardenafil, it is likely that grapefruit juice would increase the level of vardenafil in your blood, increasing your risk of side effects. It may be advisable to avoid grapefruit juice while you are taking vardenafil, until more information is available.
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